The Potential of Tracer Kinetic Studies in Drug Development Programs: A New Investigational Area for Cancer Research

Autor:	C. Prenant, Paula Wells, Robert J. A. Harte, Colin Steel, Safiye Osman, C. S. Brock, J. Luthra, Frank Brady, Julian C. Matthews, Steven R. Meikle, Patricia M Price, Terry Jones, G. Brown
Rok vydání:	1997
Předmět:	Tracer kinetic Molecular interactions medicine.medical_specialty Drug development business.industry Drug Guides Public Health Environmental and Occupational Health Normal tissue Medicine Pharmacology (medical) Pharmacology (nursing) Medical physics business
Zdroj:	Drug Information Journal. 31:1045-1049
ISSN:	2164-9200 0092-8615
DOI:	10.1177/009286159703100349
Popis:	This paper covers a unique program created in the United Kingdom between the MRC Cyclotron Unit and the CRC Phase I and II drug development committee to investigate the potential of tracer kinetic studies to investigate in vivo tumor and normal tissue kinetics, molecular interactions, pathways, and mechanism of action of novel anti-cancer agents. Positron emission tomography technology offers great potential in streamlining anti-cancer drug development programs, however, significant investment in new methodology and multidisciplinary teams is necessary.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b374a0b26e7a4587f29fc05ffe010f64 https://doi.org/10.1177/009286159703100349 Zobrazit plný text záznamu