Hyperfractionation: Fractious or Not?
| Autor: | Daphne A. Haas-Kogan, Anne Laprie, Amanda K. LaMarre |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Medulloblastoma
Cancer Research Pediatrics medicine.medical_specialty Radiation business.industry medicine.medical_treatment Cognition medicine.disease law.invention Radiation therapy Behavior Rating Inventory of Executive Function Oncology Randomized controlled trial Quality of life law Medicine Radiology Nuclear Medicine and imaging business Neurocognitive Executive dysfunction |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 88:269-271 |
| ISSN: | 0360-3016 |
| Popis: | Medulloblastoma is the most frequent brain tumor in children, and multimodality therapy generally includes surgery, chemotherapy, and craniospinal irradiation (CSI). Progressive improvements in treatment strategies have led to overall survival rates exceeding 80% for children with average-risk medulloblastoma, highlighting concerning long-term side effects that can include neurocognitive, growth, endocrine, hearing, and general quality of life impairments. In this issue of the International Journal of Radiation Oncology, Biology, Physics, Kennedy et al (1) report results of quality of survival and growth for patients treated on the primitive neuroectodermal tumor 4 (PNET4) European controlled trial of hyperfractionated (HFRT) versus conventional radiation therapy for standard-risk medulloblastoma. They found that HFRT had less impact on executive function than standard CSI but resulted in greater height impairment. The Behavior Rating Inventory of Executive Function (BRIEF) questionnaire aims to assess impairment of executive function for individuals aged 5-18 years. The BRIEF questionnaire involves 8 parameters and gives the clinician insight into the behavior and everyday function of the child or adolescent being testeddinformation that serves to complement performance measures. Of the 4main outcomemeasures, only executive function (BRIEF)was inferior in theHFRTarm,whereas the other 3 outcome measuresdhealth status, behavioral difficulties, and health-related quality of lifeddid not differ between arms. In addition, only a limited proportion of children in either radiation group (10%-23%) had BRIEF scores in the range of executive dysfunction. Because executive function has significant implications for everyday social and academic function, these results shed light on the cognitive, behavioral, and socialeemotional developmental consequences of treatment for our patients (2). |
| Databáze: | OpenAIRE |
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