NLC delivery systems for alpha lipoic acid: Physicochemical characteristics and release study
| Autor: | Elżbieta Sikora, Elwira Lasoń, Paulina Socha, Małgorzata Miastkowska, Jan Ogonowski |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Antioxidant
Chromatography Chemistry medicine.medical_treatment Alpha-Lipoic Acid Dispersity 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Controlled release 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Colloid and Surface Chemistry Membrane medicine Zeta potential Particle size Cellulose 0210 nano-technology |
| Zdroj: | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 532:57-62 |
| ISSN: | 0927-7757 |
| DOI: | 10.1016/j.colsurfa.2017.06.083 |
| Popis: | The main objective of this study was to prepare nanostructured lipid carriers as long term stable carrier systems for the topical delivery of alpha lipoic acid (ALA). The ALA-loaded NLC were prepared by the ultrasound homogenization method, using mixture of Apifil CG and Myritol 312 as the lipid phase. The systems were stabilized by Plantacare 2000 UP. The stability of obtained formulations was assessed using macroscopic and microscopic analysis. Physicochemical properties of the carriers, such as particle size, polydispersity index, zeta potential and their viscosity were studied. In vitro release studies of the active were performed at the 32 °C, using cellulose membrane and the phosphate buffer (PBS, pH = 7,4) as a receptor solution. The obtained results confirmed a high physical stability of the empty and ALA-loaded formulations and showed that the prepared systems are suitable carriers for controlled release of ALA and can be a promising solution for skin delivery of this antioxidant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect