Reactivation of Crohn’s colitis in an adolescent following serial autologous fecal transplants for diversion colitis: A case report with multiomic characterization

Autor: Esthermari Gonzalez Polanco, Maria Murach, Casandra L Hoffman, Sandra L. Oliphant, Nishikant Wase, Emily C. McGowan, Michael V. Mendoza, Sean R. Moore
Rok vydání: 2021
Popis: Autologous fecal transplant (AFT, transfer of ileostomy feces to the colon) for diversion colitis (DC) has not yet been described in children or adolescents. We performed serial AFTs in a 16-year-old with Crohn’s disease and DC. As evidenced by endoscopic, histologic, laboratory, and multiomic profiling of the colon, the first AFT led to interval improvement in DC, whereas the second AFT reactivated Crohn’s colitis. These findings ultimately guided shared decision-making towards total colectomy.
Databáze: OpenAIRE