ChemInform Abstract: An Alternative Route for Carboni-Lindsey Reaction: N,N Cycloaddition of an Alkene to s-Tetrazine

Autor:	Jacob T. Klug, Vladimir Khodorkovsky, Xiaojian Zhou, Efim G. Kovalev
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Tetrazine chemistry.chemical_compound chemistry Alkene Product (mathematics) Triazole derivatives General Medicine Pyrazole Medicinal chemistry Cycloaddition
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200137137
Popis:	Quantum mechanical calculations show that N,N cycloaddition of alkenes and alkynes to s-tetrazines is possible as an alternative to the well-known C,C cycloaddition (Carboni−Lindsey reaction). Formation of 1,2,4-triazole derivatives (formal product of N,N cycloaddition) along with the pyrazole (formal product of C,C cycloaddition) corroborates this theoretical prediction.
Databáze:	OpenAIRE
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