Road to fertility: comparison of letrozole and clomiphene citrate-estradiol valerate for ovulation induction in female with unexplained infertility to see ovulation and conception rate
| Autor: | Smriti Jain, Neetu Singh, Ruchita Bawankar |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 12:1093-1096 |
| ISSN: | 2320-1789 2320-1770 |
| DOI: | 10.18203/2320-1770.ijrcog20230819 |
| Popis: | Background: Clomiphene citrate was considered as first line of treatment for ovulation and induction in patients with unexplained infertility, but there are differences in results which can be explained by anti-estrogenic effect of CC resulting in estrogen receptor depletion. Letrozole is potent non-steroidal aromatase inhibitor which increases gonadotrophin secretion with ovarian follicle stimulation. Research question was that which drug is more efficacious for ovulation and induction in patients with unexplained infertility. Methods: This comparative study was conducted at OBGYN OPD of RMCH and RC, Kanpur. Patients were 50 females with unexplained infertility randomly divided into 2 groups. Group A received letrozole 2.5 mg from D3-D7 of menstruation. Group B received CC 50 mg from D3-D7 plus 2 mg estradiol valerate BD on D8-D14 of menstruation. Female aged 18-35 years with complete fertility workup i.e. D3 FSH, LH, prolactin, serum TSH, HSG, USG-pelvis, mid luteal phase progesterone, semen analysis within normal limits are included in study. Patients with male infertility, hyperprolactinemia, thyroid disorders and BMI>30 kg/m2 were excluded. Results: There was statistically significant difference in endometrial thickness (ET) between two groups, (p value |
| Databáze: | OpenAIRE |
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