Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold
| Autor: | Kyle C. Van de Bittner, Leyla Y. Bustamante, Jan Vorster, Rosannah C. Cameron, Matthew J. Nicholson, Sarah A. Kessans, Rudranuj Bundela, Emily J. Parker |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Indole test 010405 organic chemistry Stereochemistry Organic Chemistry Prenyltransferase Pharmaceutical Science Substrate (chemistry) 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Enzyme Biosynthesis chemistry Prenylation In vivo Drug Discovery Molecular Medicine Diterpene |
| Zdroj: | MedChemComm. 10:1160-1164 |
| ISSN: | 2040-2511 2040-2503 |
| DOI: | 10.1039/c9md00143c |
| Popis: | Prenylation of aromatic compounds is a key tailoring reaction in biosynthesis of bioactive indole-diterpenes. Here, we identify NodD1 as the enzyme responsible for the bisprenylation of nodulisporic acid F. This prenyltransferase showed a preference for its natural indole-diterpene substrate whereas other related enzymes were not able to catalyse this conversion. |
| Databáze: | OpenAIRE |
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