Effect of α2-Adrenoceptor Stimulation on Functional Parameters of Langendorff-Isolated Rat Heart
| Autor: | A. M. Kuptsova, Timur Lvovich Zefirov, Andrey L. Zefirov, N. I. Ziyatdinova, L. I. Faskhutdinov |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chronotropic Agonist Inotrope medicine.medical_specialty Contraction (grammar) medicine.drug_class Chemistry Stimulation General Medicine General Biochemistry Genetics and Molecular Biology Clonidine Hydrochloride 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Internal medicine medicine Receptor 030217 neurology & neurosurgery Coronary flow |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 165:593-596 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-018-4220-9 |
| Popis: | We studied the effect of α2-adrenoreceptor agonist clonidine hydrochloride in concentrations of 10—9-10—6 M on inotropy, chronotropy, and coronary flow in Langendorff-isolated heart of adult rats. It was found that α2-adrenoreceptor agonist changed all studied parameters. Left ventricular myocardium contraction force decreased after application of all tested concentrations, the maximum effect was observed at a concentration of 10—6 M. Stimulation of α2-adrenergic receptors in concentrations of 10—8, 10—7, and 10—6 M produced a two-phase effect (initial increase and a subsequent decrease) on the coronary flow. Clonidine hydrochloride in the maximum concentration (10—6 M) caused a decrease in HR in one group and an increase in the other. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink