Effects of Vitamin B-Complex Supplementation Alone or Combined with Estrogen on Bone Loss in Ovariectomized Rats
| Autor: | Hanan F. Al-Saeed, Bassant M.M. Ibrahim, Aziza B. Shalby |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Vitamin
medicine.medical_specialty Homocysteine business.industry medicine.drug_class Osteoporosis chemistry.chemical_element Calcium medicine.disease Bone remodeling chemistry.chemical_compound Endocrinology chemistry Estrogen Internal medicine polycyclic compounds medicine Ovariectomized rat Alkaline phosphatase business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of medical and pharmaceutical sciences. 1 |
| ISSN: | 2522-333X |
| Popis: | Background: Postmenopausal osteoporosis has become a global health issues recently. Several vitamins play a role in building and maintenance of bones. Objective: To evaluate the possible roles of vitamin B-complex supplementation alone or combined with estrogen in the improvement of osteoporosis in ovariectomized (OVX) rats. Materials and Methods: Fifty adult female albino rats were equally divided into 5 groups then 4 groups were exposed to ovariectomy: Control group, OVX group, OVX/ Ethinyl estradiol (EE) group, OVX/B-complex group and OVX/EE/B-complex only. All treatments were started 4 weeks after surgery and continued for 8 weeks. Blood samples were collected to measure serum levels of homocysteine (HCY), bone–specific alkaline phosphatase (BAP), collagen type 1 cross-linked C-telopeptide (CTX) and calcium (Ca++). Results: Ovariectomy increased serum levels of Ca++, bone turnover markers (BAP and CTX) and homocysteine (HCY). Serum Ca++ levels were increased, while serum levels of bone markers and HCY were decreased) in all treated groups but, only rats treated with EE and vitamin B-complex returned the serum levels of CTX and HCY to normal. Conclusion: Vitamin B-complex showed some antiosteoporotic effects in OVX rats. |
| Databáze: | OpenAIRE |
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