Photoinitiated stereoselective direct C(sp2)–H perfluoroalkylation and difluoroacetylation of enamides

Autor: Qing-Hong Zhang, Ying-Xue Wang, Jing-Yu Guo, Ting Guan, Ji-Yu Tao, Teck-Peng Loh, Kai Zhao, Yu Zhang, Kun Ni
Rok vydání: 2021
Předmět:
Zdroj: Organic Chemistry Frontiers. 8:4086-4094
ISSN: 2052-4129
DOI: 10.1039/d1qo00605c
Popis: A photoinitiated perfluoroalkylative coupling of enamides with perfluoroalkyl iodides and a visible-light-induced difluoroacetylation of enamides with ethyl bromodifluoroacetate have been developed, respectively. These transformations allow the efficacious and straightforward incorporation of biologically and physiologically privileged fluoro-containing moieties into synthetically eminent enamide scaffolds with excellent regio- and stereoselectivities under mild and environmentally friendly conditions.
Databáze: OpenAIRE