In Vitro and In Vivo Study of Argyreia speciosa on Chronic Gastric Ulceration and Metabolic Studies
| Autor: | Narayan Prasad Yadav, Shyam Sundar Gupta, Ch V Rao, Lubna Azmi, Ila Shukla, Padam Kant |
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| Rok vydání: | 2018 |
| Předmět: |
Antioxidant
biology business.industry medicine.medical_treatment Antagonist Cancer Pharmacology biology.organism_classification medicine.disease digestive system diseases In vitro Gastrointestinal disorder Histamine H2 receptor In vivo medicine General Agricultural and Biological Sciences business General Environmental Science Argyreia |
| Zdroj: | Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. 89:1039-1045 |
| ISSN: | 2250-1746 0369-8211 |
| DOI: | 10.1007/s40011-018-1023-8 |
| Popis: | Chronic gastric ulcer being the most prevalent gastrointestinal disorder is considered a major cause of gastric cancer. Large numbers of synthetic drugs ranging from proton-pump inhibitors and H2 receptor antagonist to cytoprotective agents are available, but they have major side effects. Inadequacy of these synthetic drugs forces to develop new herbal-based drugs active against chronic gastric ulcer. In the present study, antiulcer activity of butanolic extract of Argyreia speciosa Linn. f., Sweet: Family Convolvulaceae (b-ASL) was investigated against acetic-acid-induced chronic gastric ulcer rat models. The effect of different dose of butanolic extract of A. speciosa was studied for antioxidant, anti-secretory, and cytoprotective activities. Extract administration significantly increased the gastric PGE2 content. The further experiments including the in vitro metabolic stability and in vivo pharmacokinetics gave a clear indication that butanolic extract of A. speciosa (200 mg/kg) is an orally active and safe contender of antiulcer agents. It can be an important target for further studies under chronic ulcer management system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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