In vitroanthelmintic activity ofVepris louisiiGilbert extracts on developmental stages ofHeligmosomoides bakeri(Nematoda: Heligmosomoidae)

Autor:	Mpoame Mbida, Pierre Tane, Jeannette Yondo, Marie Claire Komtangi, J Wabo Pone
Rok vydání:	2014
Předmět:	Infective stage Veterinary medicine Larva Organic Chemistry Laboratory mouse Plant Science Biology biology.organism_classification Egg hatch assay Vepris In vitro Albendazole embryonic structures Drug Discovery medicine Anthelmintic medicine.drug
Zdroj:	Medicinal Plants - International Journal of Phytomedicines and Related Industries. 6:174
ISSN:	0975-6892 0975-4261
DOI:	10.5958/0975-6892.2014.00005.7
Popis:	Vepris louisii Gilbert, used by indigenous farmers to treat helminth infections in livestock, was screened in vitro for anthelmintic activity using free living stages of laboratory mouse hookworm, Heligmosomoides bakeri. Aqueous and organic (methanol/dichloromethane) extracts were used for egg hatch assay, while only organic extract was used for larval mortality assay. Significant effects have been observed on three (eggs, L1 and L2 larvae) of the four stages tested, with the organic extract being more effective than aqueous for egg hatch assay. Effects were dose dependent for egg hatch, and both dose and time dependent for larval mortality. The infective stage was the least susceptible. Albendazole, was not significantly different (p>0.05) from plant extract at the highest tested concentration (5000 μg/ml) on all larval stages. Vepris louisii showed promising anthelmintic properties.
Databáze:	OpenAIRE
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