| Popis: |
Purpose: This study aimed to evaluate the effect of probiotics and phototherapy combined application in comparison with phototherapy alone on bilirubin reduction in term neonates hospitalized in Iran.Methods: This clinical trial study included 150 term neonates diagnosed with neonatal jaundice. Patients were equally assigned to two groups of phototherapy with oral probiotics (PediLact drop, 10 drops daily) and phototherapy alone through a simple random sampling method. Serum Bilirubin Levels (SBL) at the time of intervention, 24, 48, and 72 hours later, duration of phototherapy, duration of hospitalization, and the need for blood transfusion were compared in the two groups.Results: The mean serum bilirubin level (SBL) on the first day of hospitalization was 15.6±1.7 mg/dl in the combinatory therapy group, and it was 15.8±1.6 mg/dl in the Monotherapy group (P=0.584). The mean serum level (SBL) on the second day in the combinatory therapy group was 11.2±2.2, and in the other group it was 12.4±2.1, and on the third day, they were 7.2±0.9 and 7.8±0.7, respectively, and the difference between the two groups was statistically significant. The mean hospital stay time in the combinatory therapy group was 2.4±0.5, and in the phototherapy group, it was 2.8±0.6 days (P = 0.001). The duration of phototherapy in the combinatory therapy group was 26.2±9.9 days, and in the phototherapy group, it was 31.4±10.3 hours (P = 0.001).Conclusions: The findings show that the addition of oral probiotics to phototherapy in neonatal jaundice treatment is associated with phototherapy duration reduction and hospital stay time. |
