Comparison of Combined Bipolar Radiofrequency Impedance-Controlled Endometrial Ablation with Levonorgestrel Intrauterine System versus Bipolar Radiofrequency Endometrial Ablation Alone in Women with Abnormal Uterine Bleeding
| Autor: | Haixia Li, Baojun Yang, Hui Zhao, Zhanqi Zhao, Limin Feng, Yinmei Dai, Hongyu Shang |
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| Rok vydání: | 2020 |
| Předmět: |
Gynecology
endocrine system medicine.medical_specialty 030219 obstetrics & reproductive medicine business.industry medicine.medical_treatment Obstetrics and Gynecology Uterine bleeding Retrospective cohort study 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Propensity score matching medicine Endometrial ablation Bipolar radiofrequency Amenorrhea Levonorgestrel In patient medicine.symptom business medicine.drug |
| Zdroj: | Journal of Minimally Invasive Gynecology. 27:774-780 |
| ISSN: | 1553-4650 |
| Popis: | Study Objective This study aims to evaluate the efficacy of the combination of bipolar radiofrequency impedance-controlled endometrial ablation (NovaSure; Hologic Inc., Bedford, MA) and levonorgestrel intrauterine system (LNG-IUS; Mirena; Schering AG, Berlin, Germany) placement in comparison with NovaSure endometrial ablation alone in patients with abnormal uterine bleeding (AUB). Design A propensity score matching study. Setting Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Patients A retrospective study was conducted on 246 patients with AUB who underwent NovaSure endometrial ablation with (NovaSure+LNG-IUS group) or without (NovaSure group) LNG-IUS between January 2013 and August 2016. To overcome selection bias, propensity score matching was used to establish a 1:1 match between these 2 groups. Accordingly, 41 patients were included in each group. Intervention NovaSure endometrial ablation, immediately followed by LNG-IUS insertion in the NovaSure+LNG-IUS group, and NovaSure endometrial ablation alone in the control group. Measurements and Main Results Follow-up assessments performed at postablation months 6, 12, and 24 revealed the following: The rate of amenorrhea (78.05% vs 46.34%, 85.37% vs 53.65%, and 87.80% vs 58.54%, respectively; p Conclusion For women with AUB, the combination of NovaSure endometrial ablation and LNG-IUS is more effective than NovaSure alone in achieving amenorrhea, alleviating dysmenorrhea and reducing reinterventions. |
| Databáze: | OpenAIRE |
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