Habitual exercisers versus sedentary subjects with Parkinson's Disease: Multimodal PET and fMRI study
| Autor: | Martin J. McKeown, Mariya V. Cherkasova, Silke Appel-Cresswell, A. Jon Stoessl, Elham Shahinfard, Vesna Sossi, Katie Dinelle, Nicole Neilson, Danielle K. Murray, Matthew A. Sacheli, Nasim Vafai, Michael Schulzer, Jessamyn McKenzie |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Raclopride medicine.medical_specialty Parkinson's disease business.industry Ventral striatum Beck Depression Inventory Striatum medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Physical medicine and rehabilitation Neurology Dopamine Finger tapping medicine Apathy Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Movement Disorders. 33:1945-1950 |
| ISSN: | 0885-3185 |
| Popis: | BACKGROUND The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum. OBJECTIVE To examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD. METHODS Eight habitual exercisers and 9 sedentary subjects completed [11 C]raclopride PET scans before and after stationary cycling to determine exercise-induced release of endogenous DA in the dorsal striatum. Additionally, functional MRI assessed ventral striatum activation during reward anticipation. All participants completed motor (UPDRS III; finger tapping; and timed-up-and-go) and nonmotor (Beck Depression Inventory; Starkstein Apathy Scale) assessments. RESULTS [11 C]Raclopride analysis before and after stationary cycling demonstrated greater DA release in the caudate nuclei of habitual exercisers compared to sedentary subjects (P |
| Databáze: | OpenAIRE |
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