Porous gelatin/poly(ethylene glycol) scaffolds for skin cells
| Autor: | Masoud Frounchi, Milad Vahidi, Susan Dadbin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Poly ethylene glycol
Materials science Mts assay food.ingredient 0206 medical engineering 02 engineering and technology Gelatin chemistry.chemical_compound food PEG ratio medicine General Materials Science Composite material Fibroblast Porosity technology industry and agriculture General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 020601 biomedical engineering medicine.anatomical_structure chemistry Chemical engineering 0210 nano-technology Wound healing Ethylene glycol |
| Zdroj: | Soft Materials. 15:95-102 |
| ISSN: | 1539-4468 1539-445X |
| DOI: | 10.1080/1539445x.2016.1268623 |
| Popis: | Biocompatible porous polymeric scaffolds provide a suitable environment for proliferation of stem cells in human body. In this research work, porous gelatin – poly(ethylene glycol), PEG, based scaffolds were prepared using combination of freeze-gelation and freeze-extraction methods. Effects of various parameters such as freezing temperature, cross-linking agent, concentrations of gelatin and PEG and their blending ratio on physical and mechanical properties, swelling ratio, porosity, pore size, and degradation rate of scaffolds were investigated. Also, proliferation of fibroblast skin cells on the scaffolds was examined by MTS assay to assess the suitability of the scaffolds in wound healing and skin regeneration. The mean pore diameters of the scaffolds ranged from 100 to 182 µm. The scaffolds with higher PEG content possessed larger pore size. On the contrary, the scaffolds prepared from higher solution concentration had smaller mean pore size, and the pores were mostly interconnected. The latt... |
| Databáze: | OpenAIRE |
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