Cytomegalovirus as a cause of immunosuppression following aortic valve replacement
| Autor: | R. Freeman, TR Graham, FK Gould, Michael P. Holden |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Advanced and Specialized Nursing
business.industry medicine.medical_treatment Congenital cytomegalovirus infection Postperfusion syndrome Immunosuppression General Medicine Perioperative 030204 cardiovascular system & hematology medicine.disease Thrombocytopenic purpura Transplantation 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Aortic valve replacement Immunity Immunology medicine Radiology Nuclear Medicine and imaging Cardiology and Cardiovascular Medicine business Safety Research |
| Zdroj: | Perfusion. 2:181-183 |
| ISSN: | 1477-111X 0267-6591 |
| DOI: | 10.1177/026765918700200306 |
| Popis: | The postperfusion syndrome, haemolytic anaemia and thrombocytopenic purpura following open heart surgery have all been attributed to acute cytomegalovirus (CMV) infection,'-3 usually acquired from perioperative transfusions of whole blood. Increased susceptibility of bacterial infections has been described,4 but only in patients who have undergone cardiac transplantation and consequently received immunosuppressive therapy. Studies have shown that CMV can suppress cell-mediated immunity in vivo and in vitro5 and impairment of neutrophil migration has been demonstrated in CMV infected mice.6 We describe a patient with impaired polymorph function associated with an acute CMV infection following aortic valve replacement. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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