Comparison of the HM-CAP and E-Plate Serum Antibody Kit for the Assessment of Helicobacter pylori Eradication in Japan
| Autor: | Kohei Kawakami, Takao Itoi, Kiyoshi Mukai, Takashi Kawai, Norihisa Noguchi, Tatsuya Aoki, Fuminori Moriyasu, Yuu Takagi, Satoru Taira, Mikinori Kataoka, Kazuo Takei, Emiko Rimbara, Jun Matsubayasiu, Masanori Sasatsu |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics biology business.industry Endoscopic biopsy Clinical Biochemistry Medicine (miscellaneous) Chronic gastritis Cancer MALT lymphoma Helicobacter pylori biology.organism_classification medicine.disease Gastroenterology Serum antibody Titer Internal medicine medicine biology.protein Antibody business |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition. 38:39-43 |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.38.39 |
| Popis: | Helicobacter pylori (H. pylori) is known to be associated with peptic ulcer, chronic gastritis, MALT lymphoma, and gastric cancer. In this study, we investigated the usefulness of a new E-plate serum antibody kit, developed in Japan using H. pylori strains isolated from Japanese patients, in the assessment of eradication, with an HM-CAP kit for comparison. The subjects were 100 H. pylori positive patients who underwent upper gastrointestinal endoscopy between October 1999 and June 2000. Eradication assessment performed using E-plate kit with the cut-off values for the delta value of the antibody titre set at −20%, −30%, and −40%, yielded sensitivity/specificity of 93.9%/85.7%, 92.4%/85.7%, and 72.7%/92.9%, respectively, for agreement rates with eradication assessments using endoscopic biopsy specimens at 2 months post-eradication therapy. Use of the HM-CAP kit with cut-off values of −5%, −10%, and −15% yielded sensitivity/specificity of 97.0%/28.6%, 83.3%/85.7%, and 53.0%/100%, respectively. These results indicated that the E-plate kit is more useful for eradication assessment in Japan. |
| Databáze: | OpenAIRE |
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