Concentration-dependent effect of hypocalcaemia onin vitroclot strength in patients at risk of bleeding: a retrospective cohort study
| Autor: | Kwok-ming Ho, C.B. Yip |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry chemistry.chemical_element 030208 emergency & critical care medicine Hematology 030204 cardiovascular system & hematology Calcium Fibrinogen medicine.disease Gastroenterology Confidence interval Surgery 03 medical and health sciences 0302 clinical medicine chemistry Interquartile range Internal medicine medicine Coagulopathy Hypocalcaemia Platelet business Partial thromboplastin time medicine.drug |
| Zdroj: | Transfusion Medicine. 26:57-62 |
| ISSN: | 0958-7578 |
| DOI: | 10.1111/tme.12272 |
| Popis: | SUMMARY Aim It is uncertain whether hypocalcaemia is associated with an increased risk of bleeding. This study assessed the dose-related relationship between ionised calcium concentrations and in vitro clot strength measured by maximum amplitude (MA) on the thromboelastograph (TEG). Methods A total of 610 patients who were at risk of bleeding or had active bleeding between 2010 and 2014 were considered in this retrospective cohort study. A scatter plot with Pearson correlation coefficient (r) and multiple linear regression was used to assess the dose-related relationship between ionised calcium concentrations and MA on the TEG. Results The mean ionised calcium of the patients was 1·10 mmol L−1 (interquartile range: 1·04–1·17) and 235 (38·5%) of them had hypocalcaemia (1 mmol L−1, during critical bleeding is recommended. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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