Areal bone mineral density and bone phosphatase activities in experimental diabetes mellitus
| Autor: | Masahiro Taniji, Tadatoshi Suruda, Masato Funasako, Kazumi Fujimoto, Hiroaki Sato, Kohsaku Uetani, Masahiro Ohata, Hisashi Fujimoto, Yuji Higashimoto, Seiji Nakai |
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| Rok vydání: | 1996 |
| Předmět: |
musculoskeletal diseases
Bone mineral medicine.medical_specialty biology business.industry Endocrinology Diabetes and Metabolism Phosphatase Acid phosphatase Osteoblast General Medicine Lumbar vertebrae musculoskeletal system medicine.disease Osteopenia Endocrinology medicine.anatomical_structure Osteoclast Diabetes mellitus Internal medicine biology.protein Medicine Orthopedics and Sports Medicine business |
| Zdroj: | Journal of Bone and Mineral Metabolism. 14:153-157 |
| ISSN: | 1435-5604 0914-8779 |
| Popis: | To investigate the mechanisms of osteopenia in diabetes mellitus induced experimentally in mice, we measured the bone mineral content, expressed as the bone mineral density per surface area (areal BMD), by dual energy X-ray absorptiometry; and we assessed the alkaline (ALP) and acid phosphatase (ACP) activities of the calvarial tissues, which are assumed to represent the functional activities of osteoblasts and osteoclasts, respectively. We found that at 8 weeks after the onset of streptozotocin-induced diabetes mellitus the areal BMD values of the total body, femurs, calvariae, and lumbar vertebrae in the diabetic group were smaller than those in the control group. As compared with the control group, the ALP/ACP activity ratio of the calvariae in the diabetic group had a tendency to be reduced at 4 weeks of diabetes when the calvarial ABMD was not different between the two groups; it was definitely reduced at 8 weeks. These results suggest that an imbalance of osteoblast and osteoclast activity might be one of the mechanisms of osteopenia in the diabetic mouse. |
| Databáze: | OpenAIRE |
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