Differential postnatal development of μ-, δ- and χ-opioid binding sites in rat brain

Autor:	Davide Verotta, Alessandra Tavani, L.E. Robson, Paola Petrillo, Hans W. Kosterlitz
Rok vydání:	1987
Předmět:	medicine.medical_specialty Endocrinology medicine.anatomical_structure Developmental Neuroscience Internal medicine Central nervous system medicine Opioid binding Biology Rat brain Developmental Biology Binding affinities
Zdroj:	Developmental Brain Research. 31:53-58
ISSN:	0165-3806
DOI:	10.1016/0165-3806(87)90082-4
Popis:	With selective labelling techniques and analysis of saturation curves it is shown that in rat brain the concentrations of μ-, δ- and χ-binding sites increase differentially during postnatal development. There are no changes in the binding affinities. The concentration (pmol/g brain) of χ-sites are first to reach adult levels, namely between 7 and 14 days after birth. Adult levels of μ-sites are attained between 14 and 21 days after birth. The most striking finding is that development of δ-sites, which are not detectable 3 days after birth by the method used, lags markedly behind that of μ- and χ-sites. The profile of development in rat brain is compared to that found previously in mouse brain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b2f460f208a324ec07064fc97cf80378 https://doi.org/10.1016/0165-3806(87)90082-4 Zobrazit plný text záznamu