Cyclic accumulation strategies for polyphasic photoimmunotherapy using the biotin-avidin system

Autor: Joerg G. Moser, Eugeny A. Lukyanets, Marina V. Demcheva, Gelii V. Ponomarev, Alexander P. Savitzki
Rok vydání: 1996
Předmět:
Zdroj: SPIE Proceedings.
ISSN: 0277-786X
DOI: 10.1117/12.260750
Popis: Polybiotinylated porphyrinoids and linear alkyl-dibiotins were used to describe accumulation behavior of avidin and POD-labelled avidin on tumor cells preincubated with biotinylated monoclonal antibodies. The accumulation behavior followed more a liner than a formerly postulated branched pattern. This allows for us to calculate necessary repeats of accumulation in order to acquire the necessary amount of sensitizer molecules per tumor cell at low concentration of tumor specific marker molecules at the cell surface.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Databáze: OpenAIRE