Synthesis and biological evaluation of benzimidazole fused ellipticine derivatives as anticancer agents
| Autor: | Palle Sadanandam, V. Naresh Kumar, L. K. Ravindranath, Venkata Ramudu Burra, Reddymasu Sreenivasulu, N. Bramhananda Reddy |
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| Rok vydání: | 2016 |
| Předmět: |
Benzimidazole
biology 010405 organic chemistry Chemistry Stereochemistry Positive control General Chemistry 010402 general chemistry biology.organism_classification 01 natural sciences 0104 chemical sciences HeLa Ellipticine chemistry.chemical_compound Cell culture medicine Human cancer Etoposide medicine.drug Biological evaluation |
| Zdroj: | Monatshefte für Chemie - Chemical Monthly. 147:599-604 |
| ISSN: | 1434-4475 0026-9247 |
| Popis: | A series of ten novel benzimidazole fused ellipticine derivatives have been synthesized and these compounds were evaluated for their antiproliferative activity against four human cancer cell lines (Zr-75-1, MCF-7, HeLa, and A-549). It is observed that all the synthesized compounds showed significant antiproliferative activity with GI50 values ranging from |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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