Habitual Physical Activity is Associated with Relative Apelin Gene Expression in Adipose Tissues Among Non-Diabetic Adults

Autor:	Maryam Zarkesh, Parvin Mirmiran, Mehdi Hedayati, Afsaneh Shemshaki, Behnaz Mahmoodi
Rok vydání:	2019
Předmět:	medicine.medical_specialty 010405 organic chemistry business.industry Physical activity Adipose tissue Bioengineering 01 natural sciences Biochemistry Molecular medicine Metabolic equivalent 0104 chemical sciences Analytical Chemistry Apelin Endocrinology Internal medicine Drug Discovery medicine Molecular Medicine business Body mass index Apelin Gene Abdominal surgery
Zdroj:	International Journal of Peptide Research and Therapeutics. 25:1573-1579
ISSN:	1573-3904 1573-3149
DOI:	10.1007/s10989-018-09800-4
Popis:	The objective of the present study was to investigate the association between the apelin gene expression and habitual physical activity among morbid obese and non-obese subjects. Visceral and subcutaneous adipose tissues were obtained from 32 morbidly obese and 32 non-obese age- and sex-matched subjects, who underwent open abdominal surgery. Physical activity was collected using a valid and reliable International Physical Activity Questionnaire (IPAQ)-long form, and the metabolic equivalent of task (MET) was calculated. The mRNA expressions of apelin gene in visceral and subcutaneous adipose tissues were analyzed by Real-Time PCR. The mean age was 39.6 years for both groups and body mass index for morbidly obese and non-obese subjects were 45.3 and 25.7 kg/m2, respectively. Apelin gene expression was more increased in morbid obese than non-obese subjects in subcutaneous (2.82 vs. 0.70,P
Databáze:	OpenAIRE
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