Conventional spectroscopic identification of biologically active imidazo-pyrimido fused acridines: In vitro anti-bacterial and anti-feedant activity
| Autor: | Selvaraj Mohana Roopan, Prabhakarn Arunachalam, Jayakannu Palaniraja, Settu Ramki, Sekar Santhosh Kumar |
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| Rok vydání: | 2017 |
| Předmět: |
biology
010405 organic chemistry Stereochemistry Vibrio parahaemolyticus Biological activity Bacillus subtilis 010402 general chemistry Condensed Matter Physics biology.organism_classification medicine.disease_cause 01 natural sciences Proteus mirabilis Atomic and Molecular Physics and Optics In vitro 0104 chemical sciences Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Staphylococcus aureus Acridine Materials Chemistry medicine Physical and Theoretical Chemistry Spectroscopy Bacteria |
| Zdroj: | Journal of Molecular Liquids. 230:634-640 |
| ISSN: | 0167-7322 |
| DOI: | 10.1016/j.molliq.2017.01.010 |
| Popis: | A series of imidazo-pyrimido fused acridines were synthesized and identified using conventional spectroscopic techniques. All the synthesized title compounds were subjected to in vitro antibacterial and insecticidal screenings. For insecticidal activity, the synthesized fused compounds are testing against two pests namely, Sitophilus oryzae (S. oryzae) and Callosobruchus maculatus (C. maculatus). For antibacterial screening, the compounds are testing against four bacteria, Bacillus subtilis (B. subtilis), Proteus mirabilis (P. mirabilis), Staphylococcus aureus (S. aureus) and Vibrio parahaemolyticus (V. parahaemolyticus). Notably, compound 8-(4-isopropylphenyl)-16-phenyl-6,7-dihydrobenzo[4′,5′]imidazo[1′,2′:1,2]pyrimido[4,5-a]acridine and 8-(2,4-dimethoxyphenyl)-16-phenyl-6,7-dihydrobenzo[4′,5′]imidazo[1′,2′:1,2]pyrimido[4,5-a]acridine were identified as the most promising applicant for further studies. |
| Databáze: | OpenAIRE |
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