Vinylogous hydroxamic acids: 5-lipoxygenase inhibitors
| Autor: | Alicia M. Green, Stephen W. Wright, Susan R. Sherk, Ronald L. Magolda, Donald Joseph-Phillip Pinto |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
chemistry.chemical_classification
biology Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry chemistry.chemical_compound Enzyme Hydroxylamine chemistry Drug Discovery Arachidonate 5-lipoxygenase biology.protein Molecular Medicine Organic chemistry Arachidonic acid Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 2:1079-1084 |
| ISSN: | 0960-894X |
| Popis: | Vinylogous hydroxamic acids were prepared as inhibitors of 5-lipoxygenase. The synthesis and preliminary SAR of these relatively unexplored compounds are described. These compounds are potent 5-lipoxygenase inhibitors which do not inhibit other enzymes of the arachidonic acid cascade. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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