Venous occlusion test: Assessment of fibrinolytic capacity by D-dimer latex agglutination test
| Autor: | J. Petäjä, Vesa Rasi, Tom Krusius, Elina Vahtera, Martti Syrjälä |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
biology Chemistry Venous occlusion medicine.medical_treatment Hematology 030204 cardiovascular system & hematology Clotted blood sample Fibrin Latex fixation test 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Immunology Fibrinolysis D-dimer biology.protein medicine Screening method 030212 general & internal medicine Plasminogen activator |
| Zdroj: | Fibrinolysis. 7:41-45 |
| ISSN: | 0268-9499 |
| DOI: | 10.1016/0268-9499(93)90053-x |
| Popis: | The fibrinolytic capacity of 36 individuals was investigated by venous occlusion (VO) test. The specific components of fibrinolysis — plasminogen activator (t-PA) and plasminogen activator inhibitor activity (PAI) - were measured before and after 20 min VO and the subjects ,were divided into good (n=24) and poor (n=12) responders according to the presence of residual PAI activity after VO test. The ranking of the patients according to residual PAI activity correlated closely with that obtained by an index entitled the net fibrinolytic capacity (nFC) that expresses the ability of secreted t-PA to overcome PAI activity. Residual PAI and nFC were further compared with a recently published screening method based on fibrin degradation (D-dimer concentration) in a clotted blood sample obtained after VO. The D-dimer concentrations measured by a semiquantitative latex agglutination test agreed closely with the ranking of patients by residual PAI and nFC and had a close correlation with the concentrations of the specific components of fibrinolysis. We conclude that D-dimer test after 20 min VO qualifies well for screening of impaired fibrinolytic capacity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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