Assessment of occupational exposure to diesel particulate matter through evaluation of 1-nitropyrene and 1-aminopyrene in surface coal miners, India
| Autor: | Krishnamurthi Kannan, M. O. Farooqui, A. J. Vanisree, Yogesh B. Pakade, Amit Bafana, Dinesh L. Wadikar, Saravanadevi Sivanesan, Anirban Middey, Pravin K. Naoghare |
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| Rok vydání: | 2021 |
| Předmět: |
Diesel exhaust
010504 meteorology & atmospheric sciences business.industry Coal mining General Medicine Environmental exposure 010501 environmental sciences Management Monitoring Policy and Law 01 natural sciences Pollution chemistry.chemical_compound chemistry 1-Nitropyrene 1-aminopyrene Environmental chemistry Biomonitoring Environmental science Coal Occupational exposure business 0105 earth and related environmental sciences General Environmental Science |
| Zdroj: | Environmental Monitoring and Assessment. 193 |
| ISSN: | 1573-2959 0167-6369 |
| Popis: | DPM (diesel particulate matter) is ubiquitously present in the mining environment and is known for mutagenicity and carcinogenicity to humans. However, its health effects in surface coal mines are not well studied, particularly in India. In this study, DPM exposure and corresponding exposure biomarkers were investigated in four different surface coal mines in Central India. To document and evaluate the DPM exposure in surface coal miners, we characterized 1-NP (1-nitropyrene) in the mining environment as surrogate for DPM using Sioutas Cascade Impactor. Exposure biomarkers were analyzed by collecting post work shift (8-h work shift) urine samples and determining the concentrations of 1-aminopyrene (1-AP) as a metabolite of 1-NP and 8-hydroxydeoxyguanosine (8OHdG) as DNA damage marker. We observed high concentration of 1-NP (7.13–52.46 ng/m3) in all the mines compared with the earlier reported values. The average creatinine corrected 1-AP and 8OHdG levels ranged 0.07–0.43 $$\mu$$ g/g and 32.47–64.16 $$\mu$$ g/g, respectively, in different mines. We found 1-AP in majority of the mine workers’ urine (55.53%) and its level was higher than that reported for general environmental exposure in earlier studies. Thus, the study finding indicates occupational exposure to DPM in all the four mines. However, the association between 1-NP level and exposure biomarkers (1-AP and 8OHdG) was inconsistent, which may be due to individual physiological variations. The data on exposure levels in this study will help to understand the epidemiological risk assessment of DPM in surface coal miners. Further biomonitoring and cohort study are needed to exactly quantify the occupational health impacts caused by DPM among coal miners. |
| Databáze: | OpenAIRE |
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