Serum uric acid as an index of impaired renal function in congestive heart failure
| Autor: | Gang Liu, Kunshen Liu, Chao Liu, Qingzhen Zhao, Yuzhi Zhen, Bao Deng, Zhenguo Ji, Li Tian, Ying Chen, Guo-Ping Ma, Yu Tian, Lishuang Ji, Yanqiu Gao, Le Wang |
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| Rok vydání: | 2012 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Creatinine business.industry Renal function urologic and male genital diseases medicine.disease chemistry.chemical_compound Endocrinology chemistry Internal medicine Heart failure medicine Cardiology Uric acid Hyperuricemia Geriatrics and Gerontology Metabolic syndrome Cardiology and Cardiovascular Medicine business Blood urea nitrogen |
| Zdroj: | Journal of Geriatric Cardiology. 9:137-142 |
| ISSN: | 1671-5411 |
| DOI: | 10.3724/sp.j.1263.2011.11281 |
| Popis: | Background Hyperuricemia is frequently present in patients with heart failure. Many pathological conditions, such as tissue ischemia, renal function impairment, cardiac function impairment, metabolic syndrome, and inflammatory status, may impact uric acid (UA) metabolism. This study was to assess their potential relations to UA metabolism in heart failure. Methods We retrospectively assessed clinical characteristics, echocardiological, renal, metabolic and inflammatory variables selected on the basis of previous evidence of their involvement in cardiovascular diseases and UA metabolism in a large cohort of randomly selected adults with congestive heart failure (n = 553). By clustering of indices, those variables were explored using factor analysis. Results In factor analysis, serum uric acid (SUA) formed part of a principal cluster of renal functional variables which included serum creatinine (SCr) and blood urea nitrogen (BUN). Univariate correlation coefficients between variables of patients with congestive heart failure showed that the strongest correlations for SUA were with BUN (r = 0.48, P < 0.001) and SCr (r = 0.47, P < 0.001). Conclusions There was an inverse relationship between SUA levels and measures of renal function in patients with congestive heart failure. The strong correlation between SUA and SCr and BUN levels suggests that elevated SUA concentrations reflect an impairment of renal function in heart failure. J Geriatr Cardiol 2012; 9: 137−142. doi: 10.3724/SP.J.1263.2011.11281 |
| Databáze: | OpenAIRE |
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