The functional role of monoanimergic and aminoacidergic mechanisms of the locus coeruleus in anxiety states of different aversive origins

Autor:	Perch Nn, Talalaenko An, Bogdanov Ba, Stakhovskiĭ IuV, Babiĭ IuV
Rok vydání:	1993
Předmět:	medicine.drug_class Stimulation General Medicine Anxiolytic General Biochemistry Genetics and Molecular Biology nervous system Dopamine Anesthesia Monoaminergic medicine Locus coeruleus Anxiety Serotonin medicine.symptom Psychology Neuroscience Microinjection medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 115:713-715
ISSN:	1573-8221 0007-4888
Popis:	Dopamine and glutamine acid microinjection in the locus coeruleus of rats does not influence the alarm state in the test of "Threatening situation" avoidance, but weakens the state of alarm in the test of "illuminated site" avoidance. The local injection of GABA and noradrenaline mesatone effect imitators in this brain formation weakens the alarm state in the test of "threatening situation" avoidance but is not effective in the test of "illuminated site" avoidance. On the contrary, the chemical stimulation of locus coeruleus by serotonin influences the anxiolytic effect in two different experimentally modelled states of alarm. The participation of locus coeruleus and acidergic mechanisms in anxiety of diverse aversive genesis is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b2b8826c6f61a5a171dcec4f662798c8 https://doi.org/10.1007/bf00791170 Zobrazit plný text záznamu Full text from SpringerLink