Radiation-Induced Cellular DNA Damage and Repair, and the Effect of Hypoxic Cell Radiosensitizers

Autor:	Orazio Sapora, E. Martin Fielden
Rok vydání:	1982
Předmět:	chemistry.chemical_compound Chemistry Cellular dna DNA repair Mutant medicine Oxygen enhancement ratio Radiation induced medicine.disease_cause Escherichia coli DNA Nucleotide excision repair Cell biology
Zdroj:	Advanced Topics on Radiosensitizers of Hypoxic Cells ISBN: 9781475704013
DOI:	10.1007/978-1-4757-0399-3_5
Popis:	Chromosomal deoxyribonucleic acid (DNA) is accepted as an important target for radiochemical damage in biological systems following ultraviolet and ionizing irradiation. Several types of experimental data support this hypothesis for numerous biological systems including both mammalian and bacterial cells. The isolation and consequent studies on several mutant strains of Escherichia coli of differing DNA repair capabilities (1,2) have helped to clarify the role of DNA as a primary target and has revealed the significance of post-irradiation cellular repair activity (Table 1).
Databáze:	OpenAIRE
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