Attributes of deficient immunity in mice receivingCoccidioides immitisspherule vaccine by the intravenous route

Autor:	G.M. Scalarone, H. B. Levine
Rok vydání:	1969
Předmět:	Infectious Diseases biology Antigen In vivo Coccidioides immitis Immunity Immunogenicity Immunology Nasal administration General Medicine Coccidioides immitis spherule biology.organism_classification Intramuscular injection
Zdroj:	Medical Mycology. 7:169-177
ISSN:	1460-2709 1369-3786
DOI:	10.1080/00362177085190311
Popis:	Mice vaccinated by intramuscular doses of Coccidioides immitis spherules (formalin-killed) acquired strong immunity to otherwise lethal infections produced by the intranasal instillation of arthrospores. However, comparable doses of vaccine given intravenously induced only weak immunity. Associated immunologic responses of delayed dermal hypersensitivity, restricted fungal proliferation in vivo, the magnitude of the inflammatory cell reaction, and the susceptibility of leukocytes to undergo lysis in the presence of blood and coccidioidal antigens were very weak in intravenously-treated mice but strong in those that had been immunized by the intramuscular route. The findings emphasize the importance of the vaccinating route in assessing immunogenicity in the Coccidioides-mouse model.
Databáze:	OpenAIRE
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