Circadian genes and risk of prostate cancer: Findings from the EPICAP study
| Autor: | Brigitte Trétarre, Yves Akoli Koudou, Xavier Rebillard, Anne Boland, Geraldine Cancel-Tassin, Olivier Cussenot, Méyomo G. Wendeu-Foyet, Delphine Bacq, Pierre-Jean Lamy, Thérèse Truong, Florence Menegaux, Jean-François Deleuze, Sylvie Cénée, Pierre Laurent-Puig, Claire Mulot |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty education.field_of_study NPAS2 Circadian clock Population Single-nucleotide polymorphism Biology medicine.disease 3. Good health 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine.anatomical_structure Prostate 030220 oncology & carcinogenesis Internal medicine medicine Circadian rhythm education PER1 |
| Zdroj: | International Journal of Cancer. 145:1745-1753 |
| ISSN: | 0020-7136 |
| DOI: | 10.1002/ijc.32149 |
| Popis: | Circadian rhythms regulate several physiological functions and genes controlling the circadian rhythm were found to regulate cell proliferation, cell cycle and apoptosis. Few studies have investigated the role of those circadian genes in prostate cancer occurrence. We aim to investigate the relationship between circadian genes polymorphisms and prostate cancer risk based on data from the EPICAP study, a population-based case-control study including 1,515 men (732 cases / 783 controls) with genotyped data. Odds Ratios (ORs) for association between prostate cancer and circadian gene variants were estimated for each of the 872 single nucleotide polymorphisms (SNPs) in 31 circadian clock genes. We also used a gene-based and pathway-based approach with a focus on the pathway including 9 core circadian genes. Separate analyses were conducted by prostate cancer aggressiveness. The core-circadian pathway (p = 0.0006) was significantly associated to prostate cancer, for either low (p = 0.002) or high (p = 0.01) grade tumor. At the gene level, we observed significant associations between all prostate cancer and NPAS2 and PER1 after correcting for multiple testing, while only RORA was significant for aggressive tumors. At the SNP-level, no significant association was observed. Our findings provide additional evidence of a potential link between genetic variants in circadian genes and prostate cancer risk. Further investigation is warranted to confirm these findings and to better understand the biological pathways involved. |
| Databáze: | OpenAIRE |
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