ChemInform Abstract: One-Pot Synthesis of 4-Amino-1,2-dihydro-3-quinolinecarboxylic Acid Derivatives

Autor:	Taichi Kitamura, Harumi Takabatake, Kazuhiro Kobayashi, Hisatoshi Konishi, Osamu Morikawa
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Magnesium Carboxylic acid One-pot synthesis chemistry.chemical_element Diisopropylamine General Medicine Medicinal chemistry Benzonitrile chemistry.chemical_compound chemistry Ethylmagnesium bromide Diethyl ether Conjugate
Zdroj:	ChemInform. 28
ISSN:	0931-7597
DOI:	10.1002/chin.199745151
Popis:	When 2-(methylamino)benzonitrile was treated successively with magnesium bis(diisopropylamide), generated in situ from the reaction of ethylmagnesium bromide and diisopropylamine, and α,β-unsaturated carboxylic acid esters in diethyl ether at 0 °C, conjugate addition and enolate–nitrile coupling proceeded sequentially to give the corresponding 4-amino-1,2-dihydro-3-quinolinecarboxylates in isolated yields ranging from 36 to 79%.
Databáze:	OpenAIRE
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