Bioactive steroidal glycosides from the marine sponge Erylus lendenfeldi
| Autor: | Joel S. Sandler, Susan L. Forsburg, D. John Faulkner |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
biology
Steroidal glycosides Chemistry Stereochemistry Organic Chemistry Saccharomyces cerevisiae Fractionation Yeast strain biology.organism_classification Biochemistry Double Strand Break Repair Sponge chemistry.chemical_compound Drug Discovery Methanol Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Tetrahedron. 61:1199-1206 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2004.11.039 |
| Popis: | Bioassay-guided fractionation of the methanol extract of Erylus lendenfeldi using engineered strains of budding yeast ( Saccharomyces cerevisiae ) has resulted in the isolation of the known compound eryloside A ( 1 ) and two new compounds, erylosides K ( 2 ) and L ( 3 ). The structures were established based mainly on 1D and 2D NMR data. The absolute stereochemistry of eryloside A, which had never been fully characterized, was determined using the modified Mosher's method. The absolute stereochemistry of eryloside K was determined by comparison with tetrahydroeryloside A. Compounds 1 – 3 exhibited selective cytotoxicity against a yeast strain ( Δrad50 ) deficient in double strand break (DSB) repair. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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