ChemInform Abstract: Dual-Action Cephalosporins Incorporating a 3′-Tertiary-Amine-Linked Quinolone
| Autor: | N H Georgopapadakou, Chung Chen Wei, Dennis D. Keith, G. Beskid, J. G. Christenson, Fred Konzelmann, Harry Allen Albrecht, K. H. Deitcher, David L. Pruess |
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| Rok vydání: | 2010 |
| Předmět: |
Carbamate
biology Tertiary amine medicine.drug_class Chemistry medicine.medical_treatment Cephalosporin Antibiotics Nanotechnology General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Quinolone Combinatorial chemistry Ciprofloxacin polycyclic compounds medicine Chemical stability Bacteria medicine.drug |
| Zdroj: | ChemInform. 25 |
| ISSN: | 0931-7597 |
| DOI: | 10.1002/chin.199423262 |
| Popis: | We have previously reported that linking quinolones to the cephalosporin 3'-position through an ester bond, a carbamate function, or a bond through a quaternary nitrogen produced cephalosporins with a dual mode of antibacterial action. We now describe a new class of dual-action cephalosporins, with greater chemical stability than those previously reported, in which the basic nitrogen of ciprofloxacin is bonded directly to the 3'-cephalosporin position, i.e., the two moieties are linked through a tertiary amine function. These compounds have demonstrated potent activity against a broad spectrum of Gram-positive and Gram-negative bacteria, including beta-lactam-resistant strains. |
| Databáze: | OpenAIRE |
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