Systemic Lupus Erythematosus
| Autor: | A. Selva-O'Callaghan, M. Vilardell-Tarrés, J. Ordi-Ros |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Abdominal pain
medicine.medical_specialty Cyclophosphamide business.industry medicine.medical_treatment Stomach Protein losing enteropathy Immunosuppression medicine.disease Gastroenterology medicine.anatomical_structure Prednisone Internal medicine Ascites medicine medicine.symptom skin and connective tissue diseases Vasculitis business medicine.drug |
| DOI: | 10.1016/b978-0-444-63707-9.00011-8 |
| Popis: | Gastrointestinal involvement affecting the oral cavity, esophagus, stomach, small bowel, or colon is common in systemic lupus erythematosus (SLE) and occasionally life-threatening if not treated promptly. Abdominal pain is sometimes the only symptom, making the diagnosis a challenge for clinicians. Usually, the clinical gastrointestinal symptoms run in parallel with SLE disease activity. Abdominal CT is useful for establishing a prompt diagnosis, as it enables visualization of the vasculature and can depict bowel abnormalities, mesenteric edema, and ascites. Chronic intestinal pseudoobstruction, protein-losing gastroenteropathy, and intestinal vasculitis are the most common identifiable SLE-related gastrointestinal manifestations. The precise pathogenesis of these conditions is uncertain, but several disease- and treatment-related factors may be implicated, such as vasculitis, cytokine-mediated damage, complement deposition, and the presence of antiphospholipid antibodies. Immunosuppression with prednisone, adding cyclophosphamide in refractory cases, is the cornerstone therapy for most SLE-related gastrointestinal manifestations. If the patient's general condition deteriorates, surgery is occasionally recommended. |
| Databáze: | OpenAIRE |
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