Antimicrobial and Modulatory Activity of Ethanol Extract of the Leaves from Lygodium venustum SW
| Autor: | Antônio A.F. Saraiva, Irwin Rose Alencar de Menezes, Saulo R. Tintino, Karla K.A. Santos, José Galberto Martins da Costa, Jacqueline Cosmo Andrade, Teógenes M. Souza, Celestina E. Sobral-Souza, Gláucia M.M. Guedes, Maria Flaviana Bezerra Morais-Braga, Henrique Douglas Melo Coutinho |
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| Rok vydání: | 2012 |
| Předmět: |
Traditional medicine
Pseudomonas aeruginosa Plant Science Biology medicine.disease_cause Antimicrobial biology.organism_classification Microbiology chemistry.chemical_compound Minimum inhibitory concentration Phytochemical chemistry medicine Gentamicin Phenols Candida albicans Escherichia coli Ecology Evolution Behavior and Systematics medicine.drug |
| Zdroj: | American Fern Journal. 102:154-160 |
| ISSN: | 1938-422X 0002-8444 |
| DOI: | 10.1640/0002-8444-102.2.154 |
| Popis: | The evolution of microorganism defense systems has led to intensive searches for new drugs extracted from various natural products to fight microbial infections. This study evaluated the antibacterial and antifungal activity of Lygodium venustum, a climbing fern. A phytochemical screening was performed using ethanol extract from leaves of L. venustum (EELV), detecting the presence of phenols, tannins, flavonoids and alkaloids. The test of Minimal Inhibitory Concentration (MIC) against Escherichia coli, Staphyloccocus aureus, Pseudomonas aeruginosa, Candida albicans, C. krusei and C. tropicalis was evaluated using the microdilution method, resulting in inhibitory concentrations ≥ 1024 µg/mL. Using a subinhibitory concentration of 128 µg/mL of EELV, the modulatory potential of the extract was tested against multidrug-resistant clinical isolates, resulting in synergism when combined with Gentamicin and actually altering the phenotype of S. aureus from sensitive to resistant. The extract also increas... |
| Databáze: | OpenAIRE |
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