Nebenwirkungen durch Trimethoprim-Sulfamethoxazol bei Patienten mit AIDS
| Autor: | H. D. Pohle, B. de Matos-Marques, B. Ruf, C. Sixt, Th. Weinke |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Leukopenia business.industry Sulfamethoxazole Retrospective cohort study General Medicine medicine.disease Trimethoprim Gastroenterology Pneumonia Acquired immunodeficiency syndrome (AIDS) Pneumocystis carinii Internal medicine Medicine medicine.symptom business Pentamidine medicine.drug |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 113:1129-1133 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-2008-1067780 |
| Popis: | Forty-nine episodes of Pneumocystis carinii pneumonia, treated with trimethoprim-sulfamethoxazole among 46 patients with AIDS were analysed retrospectively for any side effects. For only two were there insufficient data. There were 39 toxic reactions, 15 of them serious: leukopenia (n = 23), abnormal liver functions (n = 14), skin changes (n = 12), gastrointestinal complaints (n = 10) and thrombocytopenia (n = 9). In nine patients the treatment had to be discontinued, in six of them so early that a switch to pentamidine was necessary. Gastrointestinal symptoms occurred as early as the sixth day of treatment, while leukopenia and thrombocytopenia were first observed after 12-13 days. Despite the high rate of side effects trimethoprim-sulfamethoxazole remains the drugs of choice, other regimens not having been found to be any better. |
| Databáze: | OpenAIRE |
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