Poly(ethylene imine)s as Antimicrobial Agents with Selective Activity
| Autor: | Michael Urban, Katherine A. Gibney, Zachary Ridgway, Gregory A. Caputo, Iva Sovadinova, Analette I. Lopez, Kenichi Kuroda |
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| Rok vydání: | 2012 |
| Předmět: |
Polymers and Plastics
Imine technology industry and agriculture Bioengineering Depolarization macromolecular substances medicine.disease_cause Antimicrobial medicine.disease Hemolysis Biomaterials chemistry.chemical_compound chemistry Biochemistry Staphylococcus aureus Materials Chemistry medicine Structure–activity relationship Viability assay Escherichia coli Biotechnology |
| Zdroj: | Macromolecular Bioscience. 12:1279-1289 |
| ISSN: | 1616-5187 |
| DOI: | 10.1002/mabi.201200052 |
| Popis: | We report the structure-activity relationship in the antimicrobial activity of linear and branched poly(ethylene imine)s (L- and B-PEIs) with a range of molecular weights (MWs) (500-12,000). Both L- and B-PEIs displayed enhanced activity against Staphylococcus aureus over Escherichia coli. Both B- and L-PEIs did not cause any significant permeabilization of E. coli cytoplasmic membrane. L-PEIs induced depolarization of S. aureus membrane although B-PEIs did not. The low MW B-PEIs caused little or no hemolysis while L-PEIs are hemolytic. The low MW B-PEIs are less cytotoxic to human HEp-2 cells than other PEIs. However, they induced significant cell viability reduction after 24 h incubation. The results presented here highlight the interplay between polymer size and structure on activity. |
| Databáze: | OpenAIRE |
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