Tracing the genetic footprints of vertebrate landing in non-teleost ray-finned fishes
| Autor: | Yong Zhang, Huifeng Jiang, Qiwei Wei, Qiang Qiu, Miaoquan Fang, Chenglong Zhu, Min Zhu, Wen Wang, Shunping He, Daqi Yu, H.R. Zeng, Y. H. Zhu, Xiaoni Gan, Haifeng Jiang, Hao Yu, Yiran Cai, Huanming Yang, Liandong Yang, Yuming He, Guojie Zhang, Hailin Pan, Kun Wang, X. J. Bi |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Genome evolution biology Vertebrate biology.organism_classification Alligator gar Genome General Biochemistry Genetics and Molecular Biology Homology (biology) body regions 03 medical and health sciences 0302 clinical medicine Evolutionary biology biology.animal Paddlefish Bichir Bowfin 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Cell. 184:1377-1391.e14 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2021.01.046 |
| Popis: | Rich fossil evidence suggests that many traits and functions related to terrestrial evolution were present long before the ancestor of lobe- and ray-finned fishes. Here, we present genome sequences of the bichir, paddlefish, bowfin, and alligator gar, covering all major early divergent lineages of ray-finned fishes. Our analyses show that these species exhibit many mosaic genomic features of lobe- and ray-finned fishes. In particular, many regulatory elements for limb development are present in these fishes, supporting the hypothesis that the relevant ancestral regulation networks emerged before the origin of tetrapods. Transcriptome analyses confirm the homology between the lung and swim bladder and reveal the presence of functional lung-related genes in early ray-finned fishes. Furthermore, we functionally validate the essential role of a jawed vertebrate highly conserved element for cardiovascular development. Our results imply the ancestors of jawed vertebrates already had the potential gene networks for cardio-respiratory systems supporting air breathing. |
| Databáze: | OpenAIRE |
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