ChemInform Abstract: Facile Conversion of Tetracycline Antibiotics to 4,11a-Bridged Derivatives via Oxidative Mannich Cyclization

Autor:	Ping Cai, Thomas Storz, Mark Edward Ruppen, Jianxin Gu, Yumin Gong
Rok vydání:	2011
Předmět:	medicine.drug_class Chemistry Intramolecular force Yield (chemistry) Tetracycline antibiotics medicine Iminium Mercuric acetate General Medicine Oxidative phosphorylation Medicinal chemistry
Zdroj:	ChemInform. 42
ISSN:	0931-7597
DOI:	10.1002/chin.201117193
Popis:	The reaction of minocycline (I) with mercuric acetate proceeds with oxidation of a dimethylamino group followed by a novel intramolecular Mannich cyclization of an intermediate iminium cation leading to 4,11a-bridged derivative (II) in high yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b28e723ac05e559320a0e62ec4bac75d https://doi.org/10.1002/chin.201117193 Zobrazit plný text záznamu Plný text