| Popis: |
To identify characteristics of development of human pancreatic stroma in the fetal and neonatal periods of ontogenesis, we have conducted a cross prospective study of 208 pancreases of fetuses (16-40 weeks) and dead newborns. They have been divided into groups by age. Data were processed by methods of nonparametric statistics. It has been established that in pathological pregnancies, formation of the pancreas stroma components was interrupted. A reliable connection between collagen content and perinatal pathology development risk (r s = 0.145, p = 0.001) has been detected, as well as in the groups “collagen - age” and “collagen - cause of death” (r s = -0.184, p = 0.003; r s = -0.194, p = 0.005). In the group of cases caused by separate states, the content of collagen was significantly higher (p = 0.024). Conclusions: it is necessary to consider the risk of development of the perinatal pathology as one of the major factors causing overdevelopment of the pancreas stroma collagen, what reflects environmental impacts on the feto-placentary system. |
