ChemInform Abstract: The Homologous Conjugate Addition of Thiols to Electron-Deficient Cyclopropanes Catalyzed by a Calcium(II) Complex

Autor:	Caroline M. Braun, Alyssa M. Shema, Callie C. Dulin, Kristine A. Nolin
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Addition reaction chemistry Base (chemistry) Thiol chemistry.chemical_element General Medicine Electron Calcium Photochemistry Medicinal chemistry Catalysis Conjugate
Zdroj:	ChemInform. 45
ISSN:	0931-7597
DOI:	10.1002/chin.201407084
Popis:	The synthesis of γ-sulfanyl malonates was achieved through the addition of thiols to electron deficient cyclopropanes. These reactions are catalyzed by calcium acetylacetonate, Ca(acac) 2 . A variety of electron rich and electron deficient thiols were added without the need for prior activation or exogenous base. The thiol additions to donor–acceptor cyclopropanes bearing electron-rich and electron-deficient aromatic and heteroaromatic groups proceeded in good to excellent yields.
Databáze:	OpenAIRE
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