Risk factors for nursing home placement in advanced Parkinson's disease

Autor:	Margery H. Mark, Dennis W. Dickson, K. O. Schwarz, Roger C. Duvoisin, Alice Lazzarini, Lawrence I. Golbe
Rok vydání:	1993
Předmět:	Levodopa Pathology medicine.medical_specialty Lewy body business.industry Substantia nigra Disease medicine.disease Central nervous system disease symbols.namesake Degenerative disease medicine Mendelian inheritance symbols Neurology (clinical) business medicine.drug Dominance (genetics)
Zdroj:	Neurology. 43:2222-2222
ISSN:	1526-632X 0028-3878
DOI:	10.1212/wnl.43.11.2222
Popis:	The few previously reported patients with familial parkinsonism and Lewy-body pathology in the substantia nigra displayed a variety of clinical and pathologic syndromes. We now describe a family with very slowly progressive Parkinson's disease (PD) that has, in most cases, responded poorly to levodopa and includes subjective visual difficult. Four personally confirmed cases--with onset at ages 35, 25, 16, and 16-have occurred in three generations, and four suspicious cases have occurred in three other generations. There has been a trend toward progressively younger age of onset. One autopsied case showed a distribution of cell loss and Lewy bodies typical of PD. The hereditary pattern is most compatible with autosomal dominance. This kindred's illness shows that a presumably single Mendelian dominant gene can cause the clinical and pathologic features of PD, and further extends the clinical spectrum of pathologically typical Lewy-body PD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b2811b783b4a813799c882d00b73cf5e https://doi.org/10.1212/wnl.43.11.2222 Zobrazit plný text záznamu