Evaluation of variable flip angle, MOLLI, SASHA, and IR-SNAPSHOT pulse sequences for T1 relaxometry and extracellular volume imaging of the pancreas and liver

Autor: Alex Jordan Stuckey, Dominik Nickel, Liang Li, Shivriman Giri, Temel Tirkes, Chen Lin, Xuandong Zhao
Rok vydání: 2019
Předmět:
Zdroj: Magnetic Resonance Materials in Physics, Biology and Medicine. 32:559-566
ISSN: 1352-8661
0968-5243
DOI: 10.1007/s10334-019-00762-2
Popis: Compare fourT1-mapping pulse sequences for T1 relaxometry and extracellular volume (ECV) fraction of the pancreas and liver In vitro phase of this prospective study was performed on a T1 phantom, followed by imaging 22 patients. Variable flip angle (VFA), modified Look-Locker inversion recovery (MOLLI), prototype saturation recovery single-shot acquisition (SASHA), and prototype inversion recovery (IR-SNAPSHOT) pulse sequences were used to obtain T1 and ECV maps on the same 1.5 T MR scanner using the same imaging protocol. In vitro tests showed almost perfect precision of MOLLI (ρc = 0.9998), SASHA (ρc = 0.9985), and IR-SNAPSHOT (ρc = 0.9976), while VFA showed relatively less, however, substantial precision (ρc = 0.9862). Results of patient scans showed similar ECV fraction of the liver (p = 0.08), pancreas (p = 0.43), and T1 of the liver (p = 0.08) with all pulse sequences. T1 of the pancreas with MOLLI, SASHA, and IR-SNAPSHOT was statistically similar (p > 0.05). MOLLI, SASHA, and IR-SNAPSHOT provided almost perfect in vitro precision and similar T1 during in vivo scans. Similar ECV fractions of the liver and pancreas were obtained with all sequences. More refinement of pulse sequences to provide sufficient spatial coverage in one breath hold together with high precision would be desirable in abdominal imaging.
Databáze: OpenAIRE
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