| Autor: |
Debra J. Skene, Thue Bisgaard, Ismail Gögenur, Viggo B. Kristiansen, Jacob Rosenberg, Niels Christian Hjortsø, Bülent Kücükakin |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Anesthesia & Analgesia. 108:1152-1156 |
| ISSN: |
0003-2999 |
| DOI: |
10.1213/ane.0b013e31819a6cf0 |
| Popis: |
Background In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort. Methods One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured. Results Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups. Conclusions Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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