Influence of sacubitril/valsartan on diastolic parameters in patients with chronic heart failure with reduced ejection fraction

Autor: J Uzokov, M G Mukhamedova, D S Narzullaeva, G A Nosirova, D Z Orziev, I Majidov
Rok vydání: 2022
Předmět:
Zdroj: European Journal of Cardiovascular Nursing. 21
ISSN: 1873-1953
1474-5151
DOI: 10.1093/eurjcn/zvac060.017
Popis: Funding Acknowledgements Type of funding sources: None. Background Chronic heart failure (CHF) is one of the pressing issues of modern cardiology and is widely discussed lately. Chronic heart failure with reduced ejection fraction (HFrEF) is common and is concerned with poor outcomes. Not only systolic function, but also diastolic function is deteriorated in HFrEF. Thus, we hypothesized the efficacy of angiotensin converting enzyme-neprilysin inhibitors on the diastolic function of patients with HFrEF. Objective Aim of the study was to evaluate the efficacy of angiotensin converting enzyme-neprilysin inhibitor - sacubitril/valsartan on diastolic parameters in patients with CHFrEF. Material and Methods 114 patients with diagnosed HFrEF with NYHA II-III functional class patients had been enrolled in the study. Mean age of the patients was 61.12±14.4 years, male was 53%. Patients randomly were divided into two groups by 57. Group I was provided with sacubitril/valsartan whereas Group II was provided with valsartan. All anthropometric, laboratory and instrumental methods including echocardiography with Doppler were performed at baseline and after the six months of the treatment. All statistical analysis were performed with STATA software. Results Diastolic function was significantly improved after the treatment of sacubitril/valsartan in six months compared to valsartan group (P0.05). During the follow-up period group I patients have been experienced less hospitalization than group II patients were (P Conclusion Sacubitril/valsartan significantly improved diastolic function compared to valsartan in patients with HFrEF. Further studies are required with large amount of patients.
Databáze: OpenAIRE
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