The spatial-temporal dynamics of pulmonary blood flow are altered in pulmonary arterial hypertension

Autor:	Abhilash S. Kizhakke Puliyakote, G. Kim Prisk, Ann R. Elliott, Nick H. Kim, Beni Pazar, Rui Carlos Sá, Amran K. Asadi, Susan R. Hopkins
Rok vydání:	2023
Předmět:	Physiology Physiology (medical)
Zdroj:	Journal of Applied Physiology. 134:969-979
ISSN:	1522-1601 8750-7587
DOI:	10.1152/japplphysiol.00463.2022
Popis:	Using proton MRI-arterial spin labeling to obtain serial images of pulmonary perfusion, we show that global fluctuation dispersion (FDglobal), a metric of temporal fluctuations in the spatial distribution of perfusion, was significantly increased in female patients with pulmonary arterial hypertension (PAH) compared with healthy controls. This potentially indicates pulmonary vascular dysregulation. Dynamic measures using proton MRI may provide new tools for evaluating individuals at risk of PAH or for monitoring therapy in patients with PAH.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b272778c3110b6ab2624783d6ca36aa7 https://doi.org/10.1152/japplphysiol.00463.2022 Zobrazit plný text záznamu