Однонуклеотидний поліморфізм rs510432 гена автофагії 5 та розвиток «атопічного маршу» у дітей
| Autor: | O.V. Iemets |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
business.industry Single-nucleotide polymorphism Atopic dermatitis medicine.disease law.invention body regions 03 medical and health sciences 030104 developmental biology Polymorphism (computer science) law Immunology Genotype General Earth and Planetary Sciences Medicine Allele business Genotyping Polymerase chain reaction General Environmental Science Asthma |
| Zdroj: | CHILD`S HEALTH. :14-20 |
| ISSN: | 2307-1168 2224-0551 |
| DOI: | 10.22141/2224-0551.5.73.2016.78293 |
| Popis: | Objective: to determine the association between single-nucleotide polymorphism rs510432 in gene ATG5 and the development of atopic march in children, to find out the probability of clinical manifestation and the features of the clinical course of atopic diseases in individuals with different allelic variants of polymorphism. Methods. Genotyping assay of polymorphism rs510432 in gene ATG5 was performed in children with atopic diseases and apparently healthy children using real-time polymerase chain reaction. Results. The minor T allele of rs510432 in ATG5 gene was significantly more often found in patients with atopic diseases than in apparently healthy children (χ2 = 6.36; р < 0.05). The results of logistic regression demonstrated that the risk of atopic diseases in children with minor genotype is 2.4 times higher than in carriers of major genotype. The average values of forced expiratory volume in 1 second (FEV1) are significantly lower in asthma patients with minor genotype than in thereof with major genotype (Q = 2.71; р |
| Databáze: | OpenAIRE |
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